何裕隆，男，主任醫(yī)師，教授，胃腸胰外科主任，博士導(dǎo)師。醫(yī)療專長： 1.擅長于胃腸道良、惡性腫瘤的診斷與治療，率先在國內(nèi)開展超擴(kuò)大根治術(shù)（D4）、Appleby手術(shù)和Whipple手術(shù)治療進(jìn)展期胃癌，以及聯(lián)合器官簇移植治療晚期胃腸腫瘤。在胃癌根治術(shù)、全直腸系膜切除、低位保留肛門和保護(hù)性功能的直腸癌根治術(shù)、結(jié)腸“J” 型貯袋重建直腸術(shù)等方面有深入的研究和豐富的經(jīng)驗(yàn)；2.對(duì)于胰腺疾病、腹膜后腫瘤、食道癌、食道良性疾病、結(jié)直腸息肉及息肉病等有豐富的診治經(jīng)驗(yàn)，尤其在食道癌根治術(shù)、胃或結(jié)腸代食道術(shù)、保留幽門的Whipple術(shù)、全結(jié)腸切除術(shù)、消化道重建術(shù)等方面在國內(nèi)屬于領(lǐng)先水平；3.對(duì)胃腸道間質(zhì)瘤有豐富的診治經(jīng)驗(yàn)，率先開展了國內(nèi)多中性研究，建立了胃腸道間質(zhì)瘤資料庫；4、普通外科常見病和多發(fā)病的診治有豐富的臨床經(jīng)驗(yàn)，對(duì)普通外科疑難病癥的診治有獨(dú)到的見解；4.熟練應(yīng)用腹腔鏡及消化道內(nèi)鏡對(duì)胃腸道疾病進(jìn)行診斷和治療， 采用快速康復(fù)外科和微創(chuàng)外科的理念，指導(dǎo)臨床促進(jìn)病人康復(fù)。 主要研究方向： 1. 胃腸腫瘤的診治和基礎(chǔ)研究2.腫瘤淋巴結(jié)轉(zhuǎn)移機(jī)制和防治的研究3.胃腸道間質(zhì)瘤基礎(chǔ)臨床研究4.遺傳性胃腸道疾病的研究5.結(jié)直腸癌的早期診斷和外科治療6.胰腺疾病的診治與基礎(chǔ)研究科研基金 獲國家、省部級(jí)自然科學(xué)基金多項(xiàng)；參與211工程、985工程及國家自然科學(xué)基金等多項(xiàng)科研項(xiàng)目。在國內(nèi)外核心期刊發(fā)表論文200余篇，其中SCI論文20余篇?！疤岣呶赴┩饪漂熜У呐R床與基礎(chǔ)研究”分別獲得2005年度中華醫(yī)學(xué)會(huì)醫(yī)學(xué)科技進(jìn)步二等獎(jiǎng)和2005年度廣東省科技進(jìn)步二等獎(jiǎng)；“直腸癌保功能手術(shù)”獲得2006年度廣東省科技進(jìn)步一等獎(jiǎng)；“進(jìn)展期胃癌外科治療及應(yīng)用基礎(chǔ)研究”獲2009年廣東省科技進(jìn)步獎(jiǎng)二等獎(jiǎng)。 社會(huì)兼職 現(xiàn)任亞洲外科學(xué)會(huì)會(huì)員，中華醫(yī)學(xué)會(huì)外科學(xué)分會(huì)委員，中華醫(yī)學(xué)會(huì)外科學(xué)分會(huì)胃腸外科學(xué)組副組長，中國抗癌協(xié)會(huì)胃癌專業(yè)委員會(huì)副主任委員，中國醫(yī)師協(xié)會(huì)第二屆醫(yī)學(xué)教育委員會(huì)委員，中國臨床腫瘤學(xué)會(huì)（CSCO）胃腸間質(zhì)瘤專家委員會(huì)副組長，廣東省醫(yī)學(xué)會(huì)胃腸外科學(xué)分會(huì)主任委員，廣東省抗癌協(xié)會(huì)第三屆理事會(huì)常務(wù)理事，廣東省醫(yī)學(xué)會(huì)第七屆理事會(huì)理事，廣東省抗癌協(xié)會(huì)胃癌專業(yè)委員會(huì)副主委，廣東省抗癌協(xié)會(huì)胰腺癌專業(yè)委員會(huì)副主任，廣東省抗癌協(xié)會(huì)大腸癌專業(yè)委員會(huì)常委，廣東省醫(yī)學(xué)會(huì)外科學(xué)分會(huì)第八屆委員會(huì)常委，國家和廣東省自然科學(xué)基金評(píng)委，中華醫(yī)學(xué)科技獎(jiǎng)評(píng)委，廣東省科技獎(jiǎng)評(píng)委，《消化腫瘤雜志》(電子版)主編、《中華胃腸外科雜志》副主編、《中華普通外科文獻(xiàn)》編輯部副主任、Annals of Surgery、Journal of Surgical Oncology、《中華外科雜志》、《中國實(shí)用外科雜志》、《中華普通外科雜志》等10余種雜志編委。獲獎(jiǎng)情況 1.《胰島移植》榮獲1992年度衛(wèi)生部三等獎(jiǎng)和廣東省衛(wèi)生廳二等獎(jiǎng)2.《提高胃癌療效的基礎(chǔ)與臨床研究》榮獲2005年度中華醫(yī)學(xué)會(huì)科技進(jìn)步二等獎(jiǎng)和廣東省科技進(jìn)步二等獎(jiǎng)3.《直腸癌保功能手術(shù)提高患者生存質(zhì)量的序列研究》榮獲2007年度廣東省科技進(jìn)步一等獎(jiǎng)4“進(jìn)展期胃癌外科治療及應(yīng)用基礎(chǔ)研究”獲2009年廣東省科技進(jìn)步獎(jiǎng)二等獎(jiǎng)。論 著 在國內(nèi)外核心期刊發(fā)表論文200余篇，其中SCI論文20余篇。1. High expression of PRL-3 can promote growth of gastric cancer and exhibits a poor prognostic impact on patients. Wang Z, Cai SR, He YL, Zhan WH, Chen CQ, Cui J, Wu WH, Wu H, Song W, Zhang CH, Peng JJ, Huang XH. Ann Surg Oncol. 2009 Jan; 16(1):208-19.2. Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients. Wang Z, Cai SR, He YL, Zhan WH, Zhang CH, Wu H, Peng JJ, Xu JB, Zhang XH, Wang L, Song W. J Cancer Res Clin Oncol. 2009 Aug;135(8):1041-10463. Clinicopathologic features and survival of patients with colorectal mucinous,sigent-ring cell or non-mucinous adenocarcinoma:experience at an institution in southern China. Song wu.wu sui-jing,He yu-long,cai shi-rong,zhang chang-hua,zhang xin-hua and zhan wen-hua. Chinese Medical Journal. 2009,7,122(13):1486-14914．Early operation for fulminant acute pancreatitis:a possible way to decrease mortality. Yang dong-jie he yu-long,cai shi-rong,peng jian-jun,zhang chang-hua and zhan wen-hua. Chinese Medical Journal. 2009,7,122(13):1492-14945．Comparison of patients by family history with gastric and non-gastric cancer. Xue-Fu Zhou,Yu-Long He,Wu Song,Jian-Jun Peng,Chang-Hua Zhang,Wen Li,Hui Wu. World J Gastroenterol. 2009,7,15(21):2644-26506．Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds. Zhang CH, He YL, Wang FJ, Song W, Yuan XY, Yang DJ, Chen CQ, Cai SR, Zhan WH. World J Gastroenterol. 2008 Jan 14;14(2):298-3027． Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference. Wang Z, He YL, Cai SR, Zhan WH, Li ZR, Zhu BH, Chen CQ, Ma JP, Chen ZX, Li W, Zhang LJ. Int J Cancer. 2008 Sep 15; 123(6):1439-478． Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial. Yuan XY, Zhang CH, He YL, Yuan YX, Cai SR, Luo NX, Zhan WH, Cui J. Am J Surg. 2008 Nov;196(5):751-59． Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer. Cai SR, Wang Z, Chen CQ, Wu WH, He YL, Zhan WH, Zhang CH, Cui J, Wu H. Chin Med J (Engl). 2008 Dec 20;121(24):2534-810． Spleen preservation in radical surgery for gastric cardia cancer. Zhang CH, Zhan WH, He YL, Chen CQ, Huang MJ, Cai SR. Ann Surg Oncol. 2007 Apr; 14(4):1312-9.11． Vagina vasorum dissection during D2 lymphadenectomy for gastric carcinoma. Peng JJ, He YL, Zhan WH, Xiao P, Cai SR, Zhang CH, Wu H. World J Gastroenterol. 2007 Mar 28;13(12):1867-912． Clinical analysis of eight kindreds of familial adenomatous polyposis. He YL, Zhang CH, Huang MJ, Cai SR, Zhan WH, Wang JP, Wang JF. World J Gastroenterol. 2004 Dec 15;10(24):3659-61.13． Comparison of patients by family history with gastric and non-gastric cancer. Zhou XF, He YL, Song W, Peng JJ, Zhang CH, Li W, Wu H. World J Gastroenterol. 2009 Jun 7;15(21):2644-50.14． Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. SONG Wu, WU Sui-jing, HE Yu-long, CAI Shi-rong, ZHANG Changhua, ZHANG Xin-hua, et al. Chin Med J (Engl). 2009 Jul 5; 122(13):1486-1491.15． Early operation for fulminant acute pancreatitis: a possible way to decrease mortality. YANG Dong-jie, HE Yu-long, CAI Shi-rong, PENG Jian-jun, ZHANG Chang-hua and ZHAN Wen-hua. Chin Med J (Engl). 2009 Jul 5; 122(13): 1492-1494.16． Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model. Wang L, Cai SR, Zhang CH, He YL, Zhan WH, Wu H, Peng JJ. Chin Med J (Engl). 2008 Nov 5;121(21):2167-7117． (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis. Zhu BH, Zhan WH, Li ZR, Wang Z, He YL, Peng JS, Cai SR, Ma JP, Zhang CH. World J Gastroenterol. 2007 Feb 28;13(8):1162-918． Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis. Li ZR, Wang Z, Zhu BH, He YL, Peng JS, Cai SR, Ma JP, Zhan WH. Surg Today. 2007;37(8):646-5119． Effect of lymph node micrometastases on prognosis of gastric carcinoma. Wu ZY, Li JH, Zhan WH, He YL, Wan J. World J Gastroenterol. 2007 Aug 14;13(30):4122-520． Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma. Wu ZY, Li JH, Zhan WH, He YL. World J Gastroenterol. 2006 May 14;12(18):2941-421． Right hemicolectomy combined with pancreatico- duodenectomy for the treatment of colon carcinoma invading the duodenum or pancreas. Song XM, Wang L, Zhan WH, Wang JP, He YL, Lian L, Cai GF, Zhou HF, Huang BY, Lan P. Chin Med J (Engl). 2006 Oct 20; 119(20): 1740-322． Expression of E-cadherin in gastric carcinoma and its correlation with lymph node micrometastasis. Wu ZY, Zhan WH, Li JH, He YL, Wang JP, Lan P, Peng JS, Cai SR. World J Gastroenterol. 2005 May 28; 11(20):3139-4323． Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas. Chen JQ, Zhan WH, He YL, Peng JS, Wang JP, Cai SR, Ma JP. World J Gastroenterol. 2004 Mar 15; 10(6): 776-8224． The effect of FasL gene transfer to islet cells on pancreatic islet allografts. Cai SR, He YL, Huang MJ, Peng JS, Wang JP, Zhan WH. Hepatobiliary Pancreat Dis Int. 2003 May; 2(2): 308-1225． The effect of FasL expression on pancreatic islet allograft Zhan Wenhua,Cai Shirong,Wang Jianping,He Yulong,Zheng Zhangqing,Peng Junsheng. Chin Med J (Engl). 2002 Jul; 115(7): 1006-926． Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma. Ma Jinping,Zhan Wenhua,Peng Junsheng,He Yulong,Zheng Zhangqing,Cai Shirong,Wang Lei,Wang Jianping. Chin Med J (Engl). 2001 Oct; 114(10): 1068-72?！ ≈?主編和參編《消化腫瘤外科學(xué)》、《胃腸外科手術(shù)學(xué)》、《外科學(xué)》本科教材、《外科臨床手冊》、《直腸癌保肛手術(shù)》等著作。培養(yǎng)博士后、博士研究生、碩士研究生多名。
德州
