劉凌波,醫(yī)學博士, 留美博士后,三級教授,主任醫(yī)師,博士和碩士研究生導師,美國血液病學會會員。從1984年始從事血液臨床和醫(yī)學研究,對各種血液?。ò籽 ⒘馨土?、多發(fā)性骨髓瘤、骨髓增生異常綜合征等)的診治積累了較豐富的經(jīng)驗, 特別重視根據(jù)經(jīng)驗實施個體化治療。 主要研究方向:造血干細胞衰老調(diào)控與臨床。目前主要致力于(1)尋找靶向清除急性髓系白血病干細胞,根治白血病的新思路;(2)尋找造血干細胞衰老相關疾病的機制與治療靶;(3)造血干細胞擴增的有效途徑。已主持4項國家自然科學基金面上研究項目和多項國家重點實驗室或省部或市校級項目。 門診時間:周三全天。 附: 華中科技大學同濟醫(yī)學院附屬協(xié)和醫(yī)院血液病研究所劉凌波課題組博士和碩士研究生招聘 1.要求:具有強烈的事業(yè)心,熱愛科學研究,思維活躍,富有責任心,能吃苦耐勞,具有良好團隊合作精神,良好的中英文表達能力。 2.特別歡迎有碩士和博士連讀的有志青年報考。 3.也歡迎其導師無課題經(jīng)費又對我們的研究方向感興趣的博士研究生加盟。 目前主持的在研課題:國家自然科學基金面上項目和其它研究項目共3項。 近期發(fā)表的代表性論文: 1.Danyue Peng*, Huifang Wang*, Lei Li*, Xiao Ma, Ying Chen, Hao Zhou1, Yi Luo#, Yin Xiao#, and Lingbo Liu#.miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.Leukemia. 2018 May;32(5):1180-1188. doi: 10.1038/s41375-018-0015-2. Epub 2018 Feb 2.(IF 11.7) 2.Dan-yue PENG , Hui SONG , Ling-bo LIU.Resveratrol-downregulated Phosphorylated Liver Kinase B1 Is Involved in Senescence of Acute Myeloid Leukemia Stem Cells.J Huazhong Univ Sci Technol[Med Sci]2015; 35(4):645-648,(IF:0.838) 3.Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D.Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.Blood. 2014 May 15;123(20):3105-15.(IF:10.452) 4.Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L.Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence.Transplantation. 2013 2014 Jan 15;97(1):20-9.(IF 3.828) 5.Yin Xiao, Jie Wang, Hui Song, Ping Zou, Daohong Zhou,Lingbo Liu. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence.Leukemia Research 37 (2013) 333– 340 (IF:2.923) 6.Yin XIAO, Ping ZOU, Jie WANG, Hui SONG, Jing ZOU, Lingbo LIU. Lower Phosphorylation of p38 MAPK Blocks the Oxidative Stress-induced Senescence in Myeloid Leukemic CD34+CD38– Cells. J Huazhong Univ Sci Technol[Med Sci]32(3):328-333,2012(IF:0.834) 7.Jing Zou, Ping Zou, Jie Wang, Lei Li , Yong Wang , Daohong Zhou and Lingbo Liu. Inhibition of p38 MAPK Activity Promotes ex vivo Expansion of Human Cord Blood Hematopoietic Stem Cells. Annals of Hematology; (2012) 91:813–823 (2010 IF:2.688 )。 8. Zou J, Zou P, Lou Y, Xiao Y, Wang J, Liu L. The cross-talk between ROS and p38MAPKα in the Ex Vivo expanded human umbilical cord blood CD133(+) cells. J Huazhong Univ Sci Technolog Med Sci. 2011 Oct 31,31(5):591-5.(IF:0.834) 9.Luo Y, Zou P, Zou J, Wang J, Zhou D, Liu L. Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner. Exp Gerontol.,Epub 2011 Jul 23.46(11):860-7. 2011 Nov. (IF:4.037) 10. Wang Y, Liu L, Pazhanisamy SK, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radical Biology & Medicine, January 2010,48:348-356. (IF:6.081) 11.Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury. Radiat Res. 2011 Dec;176(6):743-52. Epub 2011 Oct 20.(IF: 2.578) 12.Wang Y, Kellner J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion.Stem Cells Dev. 2011 Jul;20(7):1143-52. Epub 2011 Feb 24. (IF: 4.791) 研究生培養(yǎng)情況: 1.已畢業(yè)博士研究生:6人(均留本校血液科或其它相關部門工作,其中4人因表現(xiàn)優(yōu)秀曾經(jīng)被推薦到美國合作實驗室進行過博士后研究)。 2.已畢業(yè)碩士研究生:5人(1人已獲得美國Ph.D并在美國發(fā)展,其它均在國內(nèi)三甲醫(yī)院血液或血液腫瘤科工作)。 研究生培養(yǎng)特色: 本人掌握本領域前沿研究動態(tài),根據(jù)本人在USA博士后工作經(jīng)驗進行培養(yǎng),確保充分的時間與本組成員定期認真討論,優(yōu)秀者可直接推薦到美國合作實驗室從事博士后研究。